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Preprints from Calu Lab

Full list of publications and Research Gate profile

Preprints: We value your feedback! 

Martin, DA, Delgado, A. Calu, DJ. (2024) The psychedelic, DOI, increases dopamine release in nucleus accumbens to predictable rewards and reward cues. bioRxiv 2024.03.29.587390; doi:

Recent Publications from Calu Lab: 

Bacharach, S.Z., Martin, DA,  Stapf, CA,  Sun, F,  Li, Y, Cheer, JF, Calu, DJ (2023). Decreased ventral tegmental area CB1R signaling reduces sign-tracking and shifts cue-outcome dynamics in rat nucleus accumbens. The Journal of Neuroscience. 21 June 2023, 43 (25) 4684-4696; PMID: 37208179

Utsav Gyawali, David A Martin, Fangmiao Sun, Yulong Li, Donna Calu (2023) Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations. eLife 12:e81980


Keefer SE, Kochli, DE, Calu, DJ. (2022) Basolateral amygdala to insular cortex projections make sign-tracking behavior insensitive to outcome value. eNeuro. 9 (5) ENEURO.0156-22.2022.

Martin, D. A., Keefer, S. E., and Calu, D. (2022) Investigating discriminative stimulus modulation of opioid seeking after conflict‑induced abstinence in sign‑ and goal‑tracking rats. Psychopharmacology. Published online Aug 16 2022.  doi: 10.1007/s00213-022-06204-7

Keefer, SE, Gyawali, U., Calu, DJ. (2021). Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making. Behav. Brain Res.;409:113306. doi: 10.1016/j.bbr.2021.113306. Online ahead of print.

Kochli, DE, Keefer, SE Gyawali, U, Calu, DJ. (2020) Basolateral Amygdala to Nucleus Accumbens Communication Differentially Mediates Devaluation Sensitivity of Sign- and Goal-Tracking Rats.  Front. Behav. Neurosci. 14:593645.

Gyawali, UG, Martin, DA, Sulima, A, Rice, KC, Calu, DJ. (2020) Role of BNST CRFR1 receptors in incubation of fentanyl seeking. Front. Behav. Neurosci. 14:153.

Martin, DA, Gyawali, U, Calu, DJ. (2020) Effects of 5-HT 2A Receptor Stimulation on Economic Demand for Fentanyl After Intermittent and Continuous Access Self-Administration in Male Rats. Addict Biol. 2020 May 26; e12926. doi: 10.1111/adb.12926. Online ahead of print.

Keefer SE, Bacharach, SB, Kochli, DE, Chabot, JM, Calu, DJ. (2020) Effects of limited and extended Pavlovian training on devaluation sensitivity of sign-and goal-tracking rats. Front. Behav. Neurosci., 04 February 2020 |

Bacharach SZ, Calu DJ (2019) Stability of individual differences in sucralose taste preference. PLOS ONE 14(5): e0216431.

Bacharach, SZ*, Nasser, HM*, Zlebnik, NE, Dantrassy, HM, Cheer, JF, Calu, DJ. (2018) Cannabinoid receptor-1 signaling contributions to sign-tracking and conditioned reinforcement in rats. Psychopharmacology doi: 10.1007/s00213-018-4993-6 *equal contribution.


Nasser, HM, Lafferty, DL, Lesser, EN, Bacharach, SZ, Calu, DJ. (2017). Disconnection of basolateral amygdala and insular cortex disrupts conditioned approach in Pavlovian lever autoshaping. Neurobiology of Learning and Memory. 2017 Nov 21;147:35-45. 

Nasser, HM*, Chen, YW*, Fiscella, KA, Calu, DJ. (2015) Individual variability in behavioral flexibility predicts sign-tracking tendency.Frontiers in Behavioral Neuroscience. Nov 3; published online. *Authors contributed equally to this work.


Chen, YW, Fiscella, KA, Bacharach, SZ, Tanda, G, Shaham, Y, Calu, DJ. (2014) Effect of yohimbine on reinstatement of operant responding in rats is dependent on cue contingency but not food reward history. Addiction Biology. Epub ahead of print Jul 27, 2014.


Chen, YW, Fiscella, KA, Calu, DJ. (2014) Effect of cafeteria diet history on cue-, pellet-priming-, and stress-induced reinstatement of food seeking in female rats. PLoS One. Jul 15; 9(7):e102213.

Collaborative work:

Moin Afshar, N, Cinotti, F, Martin, D, Khamassi, M, Calu, DJ, Taylor, J, Groman, S. (2022) Conserved reward-mediated, reinforcement-learning mechanisms in Pavlovian and instrumental tasks. The Journal of Neuroscience.  10.1523/JNEUROSCI.1113-22.2022.


Lee, B, Gentry, RN, Bissonette, GB, Herman, RJ, Mallon, JJ, Bryden, DW, Calu, DJ, Schoenbaum, G, Coutureau, E, Marchand, AR, Khamassi, M, and Roesch, MR. (2018) Manipulating the revision of reward value during the intertrial interval increases sign tracking and dopamine release. PLoS Biology;16(9):e2004015. PMCID: PMC6175531

Previous work:

Calu DJ, Kawa AB, Marchant NJ, Navarre BM, Henderson MJ, Chen B, Yau H-J, Bossert JM, Schoenbaum G, Deisseroth K, Harvey BK, Hope BT, Shaham Y. (2013) Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats. Journal of Neuroscience. 33(1):214-26.


Calu, DJ, Roesch, MA, Haney, RZ, Holland, P.C., Schoenbaum, G. (2010). Neural correlates of variations in event processing during learning in central nucleus of amygdala. Neuron. 68(5);991-1001.


Roesch MA, Calu DJ, Esber GR, Schoenbaum G. (2010) Neural correlates of variations in event processing during learning in basolateral amygdala. Journal of Neuroscience. 30(7):2464-71.


Calu, DJ*, Roesch MA*, and Schoenbaum G. (2007) Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards. Nature Neuroscience. 10(12):1615-24. *Authors contributed equally to this work. 

Calu DJ, Stalnaker TA, Franz TM., Singh T, Shaham Y, and Schoenbaum G.  (2007)  Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats.  Learning and Memory. 14:325-328.

Calu  DJ, Roesch MA, Stalnaker TA, and Schoenbaum G.  (2007)  Associative encoding in posterior piriform cortex during odor discrimination and reversal learning.  Cerebral Cortex.  17:1342-1349.


*Authors contributed equally to the work.


Nasser HM, Calu DJ, Schoenbaum G and Sharpe MJ. (2017) The dopamine prediction error: contributions to associative models of reward learning. Front. Psychol. 8:244.

Kourrich, S, Calu, DJ, Bonci, A. (2015) Intrinsic plasticity: an emerging player in addiction. Nature Reviews Neuroscience. 16(3):173-8.

Calu, DJ, Chen, YW, Kawa, AB, Shaham, Y. (2014) The use of the reinstatement model to study relapse to palatable food seeking during dieting. Neuropharmacology NIDA 40th Anniversary Special Issue. 76 (B):395–406. 

Bossert JM, Marchant NJ, Calu DJ, Shaham Y. (2013) The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research. Psychopharmacology. 229(3):453-76. 

Badiani A, Belin D, Epstein DH, Calu DJ, Shaham Y. (2011) Opiate versus psychostimulant addiction: the differences do matter. Nature Reviews Neuroscience. 12(11):685-700.


Roesch MR, Calu DJ, Esber GR, Schoenbaum G. (2010) All that glitters ... dissociating attention and outcome expectancy from prediction errors signals. Journal of Neurophysiology. 104(2):587-95.

Roesch MA, Calu DJ, Burke K.A., and Schoenbaum G.  (2007)  Should I stay or should I go?  Transformation of time-discounted rewards in orbitofrontal cortex and associated brain circuits.  Annals of the New York Academy of Sciences. 1104:21-34.


Stalnaker TA, Roesch MA, Burke K.A., Calu DJ, and Schoenbaum G.  (2007) Neural correlates of inflexible behavior in the orbitofrontal-amygdalar circuit after cocaine exposure.  Annals of the New York Academy of Sciences. 1121:598-609.


Martin, DA, Calu, DJ (2019). Probing the Motivational Circuitry of Binge Eating. Neuropsychopharmacology. 2019 Nov 18. Online ahead of print. DOI: 10.1038/s41386-019-0568-4

Calu, D, Nasser, H, Shaham, Y. (2015) Unexpected results on the role of nucleus accumbens dopamine in stress-induced relapse. Biological Psychiatry. 77(10):848-9.

Caprioli D, Calu D, Shaham Y. (2014) Loss of phasic dopamine: a new addiction marker? Nature Neuroscience. 17(5):644-6.

Pickens CL, Calu DJ, (2011) Alcohol reward, dopamine depletion, and GDNF. Journal of Neuroscience. 31(42):14833-4.

Calu DJ, Schoenbaum G. (2008). Cocaine-paired cues activate aversive representations in accumbens neurons. Preview. Neuron. 57(5):633.

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